David R. Sherman, Full Professor and Associate Director of Center for Infectious Disease Research, Seattle, U.S.A.Research Interests: 1) Tuberculosis；2) Systems biology；3) Drug discovery；4) Pathogenesis；5) Gene expression.Few infectious diseases in history have had the intimate, long-term association with humans and the profound global impact of tuberculosis (TB). Today, there are nearly 16 million active cases of TB causing 1.4 million deaths annually, and the World Health Organization estimates that roughly 25% (1.8 billion people) of the world population carries tuberculosis. TB causes untold morbidity and mortality, and the work in the Sherman lab is focused on developing novel drugs and diagnostics to combat this devastating disease.