Xiaole Shirley Liu X.ShirleyLiuisacomputationalbiologistwithexpertiseincancerepigenetics.HerresearchfocusisbyintegratingdatafromChIP-seq,RIP-seq,DNase-seq,MNase-seq,RNA-seq,andotherhighthroughputgenomicsdatatomodelthespecificityandfunctionoftranscriptionfactors,chromatinregulatorsandlncRNAsintumordevelopment,progression,drugresponseandresistance.Herlaboratorydevelopedanumberofwidelyusedalgorithmsfortranscriptionfactormotiffinding,ChIP-chip/seqandDNase-seqdataanalysis.Inepigenetics,sheandcolleaguesgeneratedthefirsthighthroughputnucleosomemapinthehumangenomeandwerethefirsttousethedynamicsofnucleosomeandDNasehypersensitivitytopredictdrivingtranscriptionfactorsandtheirgenome-widebindinginabiologicalprocess.Incancerbiology,sheandcolleaguesidentifiedthefunctionofestrogenreceptor,androgenreceptor,andFoxA1inbreastandprostatecancers,foundthedirecttargetsofNOTCH1inT-LL,andreportedtheswitchofEZH2fromatranscriptionalrepressoraspartofthePRC2toatranscriptionalco-activatorinhormoneindependentprostatecancers.
X.ShirleyLiuisacomputationalbiologistwithexpertiseincancerepigenetics.HerresearchfocusisbyintegratingdatafromChIP-seq,RIP-seq,DNase-seq,MNase-seq,RNA-seq,andotherhighthroughputgenomicsdatatomodelthesp...
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