个人简历
1979年2月出生于浙江省
1997-2001 兰州大学, 学士（导师： 李裕林教授）
2001-2005 兰州大学，研究生学习（导师：李裕林教授）
2005-2007 Brandeis University, 硕士（导师：余金权教授）
2007-2012 The Scripps Research Institute, 博士（导师：余金权教授）
2012-2014 Postdoctoral Research Associate, University of Utah（导师：Prof. Matthew S. Sigman）
2014- 中国科学院上海有机化学研究所金属有机化学国家重点实验室，研究员
研究方向
小分子活化，水裂解，甲烷氧化
过渡金属催化的高选择性反应研究
不对称催化，催化剂设计以及反应机理研究
电化学在金属有机化学中的应用
获奖及荣誉
“Thieme Chemistry Journals Award”, 2016
“Shanghai Pujiang Talent Plan”, 2015
Travel Award, University of Utah, 2013
Chinese Government Award for Outstanding Self-Financed Students Abroad, 2009
Best Poster in Chemistry Award-TSRI Symposium, 2009
代表论著
1. Yang, Q.-L.; Wang, X. Y.; Weng, X.-J.; Yang, X.; Xu, X.-T.; Tong, X.; Fang, P.; Wu, X.-Y.; Mei, T.-S.* “Palladium-Catalyzed ortho-Selective C–H Chlorination of Arenes Using Anodic Oxidation” Acta Chim. Sinica 2019, 77, xxxx–xxxx. DOI: 10.6023/A19040135
2. Sun, X.; Ma, H.-X.; Mei, T.-S.; Fang, P.*; Hu, Y.* “Elecrochemical Radical Formyloxylation–Bromination, –Chlorination, and –Trifluoromethylation of Alkenes. Org. Lett. 2019, 21, 3167–3171.
3. Yang, Q.-L.; Wang, X. Y.; Wang, T.-L.; Yang, X.; Liu, D.; Tong, X.; Wu, X.-Y.; Mei, T.-S.* “Palladium-Catalyzed Electrochemical C–H Bromination Using NH4Br as the Brominating Reagent” Org. Lett. 2019, 21, 2645–2649.
4. Ma, C.; Zhao, C.-Q.; Xu, X.-T.; Li, Z.-M.; Wang, X.-Y.; Zhang, K.; Mei, T.-S.* Nickel-Catalyzed Carboxylation of Aryl and Heteroaryl Fluorosulfates Using Carbon Dioxide. Org. Lett. 2019, 21, 2464–2467.
5. Zhao, C.-Q.; Chen, Y.-G.; Qiu, H. Wei, L.; Fang, P.; Mei, T.-S.* “Water as a Hydrogenating Agent: Stereodivergent Pd-Catalyzed Semihydrogenation of Alkynes” Org. Lett. 2019, 21, 1412–1416.
6. Chen, Y.-G.; Shuai, B.; Xu, X.-T.; Li, Y.-Q.; Yang, Q.-L.; Qiu, H.; Zhang, K. Fang, P.; Mei, T.-S.* “Nickel-catalyzed Enantioselective Hydroarylation and Hydroalkenylation of Styrenes” J. Am. Chem. Soc. 2019, 141, 3395–3399.
7. Liu, D.; Ma, H.-X.; Fang, P.; Mei, T.-S.* “Nickel-Catalyzed Thiolation of Aryl Halides and Heteroaryl Halides via Electrochemistry” Angew. Chem. Int. Ed. 2019, 58, 5033–5037.
8. Yang, Q.-L.; Li, C.-Z.; Zhang, L.-W.; Li, Y.-Y.; Tong, X.; Wu, X.-Y.; Mei, T.-S.* “Palladium-Catalyzed Electrochemical C？H Alkylation of Arenes” Organometallics 2019, 38, 1208–1212.
9. Yang, Q.-L.; Wang, X.-Y.; Lu, J.-Y.; Zhang, L.-P.; Fang, P.; Mei, T.-S.* “Copper-Catalyzed Electrochemical C–H Functionalization of Arenes with Secondary Amines” J. Am. Chem. Soc. 2018, 140, 11487–11494.
10. Ma, C.; Fang, P.; Mei, T.-S.* “Recent Advances in C–H Functionalization Using Electrochemical Transition Metal Catalysis” ACS. Catal. 2018, 8, 7179–7189.
11. Jiao, K.-J.; Li, Z.-M.; Xu, X.-T.; Zhang, L.-P.; Li, Y.-Q.; Zhang, K.; Mei, T.-S.* “Palladium-catalyzed reductive electrocarboxylation of allyl esters with carbon dioxide” Org. Chem. Front. 2018, 5, 2244–2248.
12. Chen, Y.-G.; Xu, X.-T.; Zhang, K.; Li, Y.-Q.; Zhang, L.-P.; Fang, P.; Mei, T.-S.* “Transition-Metal-Catalyzed Carboxylation of Organic Halides and Their Surrogates with Carbon Dioxide” Synthesis 2018, 50, 35–48.
13. Yang, Q.-L.; Fang, P.; Mei, T.-S.* “Recent Advances in Organic Electrochemical C–H Functionalization” Chin. J. Chem. 2018, 36, 338–352.
14. Chen, Y.-G.; Shuai, B.; Ma, C.; Zhang, X.-J.; Fang, P.; Mei, T.-S.* “Regioselective Ni-Catalyzed Carboxylation of Allylic and Propargylic Alcohols with Carbon Dioxide” Org. Lett. 2017, 19, 2969–2972.
15. Li, Y.-Q.; Yang, Q.-L.; Fang, P.; Mei, T.-S.*; Zhang, D.* “Palladium-Catalyzed C(sp2)–H Acetoxylation via Electrochemical Oxidation” Org. Lett. 2017, 19, 2905–2908.
16. Ma, C.; Zhao, C.-Q.; Li, Y.-Q.; Zhang, L.-P.; Xu, X.-T.; Zhang, K.; Mei, T.-S.* “Palladium-catalyzed C–H activation/C–C cross-coupling reactions via electrochemistry” Chem. Commun. 2017, 53, 12189–12192.
17. Jiao, K.-J.; Zhao, C.-Q.; Fang, P.; Mei, T.-S.* “Palladium-catalyzed C–H functionalization with electrochemical oxidation” Tetrahedron Lett. 2017, 58, 797–802.
18. Yang, Q.-L.; Li, Y.-Q.; Ma, C.; Fang, P.; Zhang, X.-J.; Mei, T.-S.* “Palladium-Catalyzed C(sp3)–H Oxygenation via Electrochemical Oxidation” J. Am. Chem. Soc. 2017, 139, 3293–3298.
19. Liu, T.; Mei, T.-S.; Yu, J.-Q.* “gamma, delta, epsilon-C(sp3)–H Functionalization through Directed Radical H-Abstraction” J. Am. Chem. Soc. 2015, 137, 5871–5874.
20. Mei, T.-S.; Patel, H. H.; Sigman, M. S.* “Enantioselective construction of remote quaternary stereocentres” Nature 2014, 508, 340–344.
21. Mei, T.-S.; Werner, E. W.; Burckle, A. J.; Sigman, M. S.* “Enantioselective Redox-Relay Oxidative Heck Arylations of Acyclic Alkenyl Alcohols using Boronic Acids” J. Am. Chem. Soc. 2013, 135, 6830–6833.
22. Mei, T.-S.; Leow, D.; Xiao, H.; Laforteza, B.; Yu, J.-Q.* “Synthesis of Indolines via Pd(II)-Catalyzed Amination of C–H Bonds” Org. Lett. 2013, 15, 3058–3061.
23. Werner, E. W.; Mei, T.-S.; Burckle, A. J.; Sigman, M. S.* “Enantioselective Heck Arylations of Acyclic Alkenyl Alcohols Using a Redox-Relay Strategy” Science 2012, 338, 1455–1458.
24. Leow, D.; Li, G.; Mei, T.-S.; Yu, J.-Q.* “Activation of remote meta-C–H Bonds assisted by an 'end-on' template” Nature 2012, 486, 518–522.
25. Mei, T.-S.; Kou, L.; Engle, K. M.; Yu, J.-Q.* “Heterocycle Formation via Palladium-Catalyzed C–H Funtionalization” Synthesis 2012, 44, 1778–1791.
26. Engle, K. M.; Mei, T.-S.; Wasa, M.; Yu, J.-Q.* “Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions” Acc. Chem. Res. 2012, 45, 788–802.
27. Engle, K. M.; Mei, T.-S.; Wang, X.; Yu, J.-Q.* “Bystanding F+ Oxidants Enable Selective Reductive Elimination from High-Valent Metal Centers in Catalysis” Angew. Chem. Int. Ed. 2011, 50, 1478–1491.
28. Yoo, E. J.; Ma, S.; Mei, T.-S.; Chan, K.; Yu, J.-Q.* “Pd(II)-Catalyzed Intermolecular C–H Amination with Alkylamine Surrogates” J. Am. Soc. Chem. 2011, 133, 7652–7655.
29. Mei, T.-S.; Wang, D.-H.; Yu, J.-Q.* “Expedient Drug Synthesis and Diversification via ortho-C–H Iodination Using Recyclable PdI2 as the Precatalyst” Org. Lett. 2010, 12, 3140–3143.
30. Vikers, C. J.; Mei, T.-S.; Yu, J.-Q.* “Pd(II)-Catalyzed o-C–H Acetoxylation of Phenylalanine and Ephedrine Derivatives with MeCOOOtBu/Ac2O” Org. Lett. 2010, 12, 2511–2513.
31. Mei, T.-S.; Wang, X.; Yu, J.-Q.* “Pd(II)-Catalyzed Amination of C–H Bonds Using Single-Electron or Two-Electron Oxidants” J. Am. Chem. Soc. 2009, 131, 10806–10807.
32. Wang, X.; Mei, T.-S.; Yu, J.-Q.* “Versatile Pd(OTf)2？2H2O-Catalyzed ortho-Fluorination Using NMP as a Promoter” J. Am. Chem. Soc. 2009, 131, 7520–7521.
33. Wang, D.-H.; Mei, T.-S.; Yu, J.-Q.* “Versatile Pd(II)-Catalyzed C？H Activation/Aryl？Aryl Coupling of Benzoic and Phenyl Acetic Acids” J. Am. Chem. Soc. 2008, 130, 17676–17677.
34. Li, J.-J.; Mei, T.-S.; Yu, J.-Q.* “Synthesis of Indolines and Tetrahydroisoquinolines from Arylethylamines by PdII-Catalyzed C–H Activation Reactions” Angew. Chem. Int. Ed. 2008, 47, 6452–6455.
35. Mei, T.-S.; Giri, R.; Maugel, N.; Yu, J.-Q.* “PdII-Catalyzed Monoselective ortho-Halogenation of C–H Bonds Assisted by Counter Cations: a Complementary Method to Directed ortho-Lithiation” Angew. Chem. Int. Ed. 2008, 47, 5215–5219.
承担科研项目情况
2018/6–2020/6 上海科委基础研究项目
2018/1–2021/12 国家自然科学基金面上项目
2016/1–2019/12 国家自然科学基金面上项目
2015/7–2017/6 上海市浦江人才计划
2015/1–2017/12 国家自然科学基金创新研究群体基金
全部服务领域
个人简历
1979年2月出生于浙江省
1997-2001 兰州大学, 学士（导师： 李裕林教授）
2001-2005 兰州大学，研究生学习（导师：李裕林教授）
2005-2007 Brandeis University, 硕士（导师：余金权教授）
2007-2012 The Scripps Research Institute, 博士（导师：余金权教授）
2012-2014 Postdoctoral Research Associate, University of Utah（导师：Prof. Matthew S. Sigman）
2014- 中国科学院上海有机化学研究所金属有机化学国家重点实验室，研究员
研究方向
小分子活化，水裂解，甲烷氧化
过渡金属催化的高选择性反应研究
不对称催化，催化剂设计以及反应机理研究
电化学在金属有机化学中的应用
获奖及荣誉
“Thieme Chemistry Journals Award”, 2016
“Shanghai Pujiang Talent Plan”, 2015
Travel Award, University of Utah, 2013
Chinese Government Award for Outstanding Self-Financed Students Abroad, 2009
Best Poster in Chemistry Award-TSRI Symposium, 2009
代表论著
1. Yang, Q.-L.; Wang, X. Y.; Weng, X.-J.; Yang, X.; Xu, X.-T.; Tong, X.; Fang, P.; Wu, X.-Y.; Mei, T.-S.* “Palladium-Catalyzed ortho-Selective C–H Chlorination of Arenes Using Anodic Oxidation” Acta Chim. Sinica 2019, 77, xxxx–xxxx. DOI: 10.6023/A19040135
2. Sun, X.; Ma, H.-X.; Mei, T.-S.; Fang, P.*; Hu, Y.* “Elecrochemical Radical Formyloxylation–Bromination, –Chlorination, and –Trifluoromethylation of Alkenes. Org. Lett. 2019, 21, 3167–3171.
3. Yang, Q.-L.; Wang, X. Y.; Wang, T.-L.; Yang, X.; Liu, D.; Tong, X.; Wu, X.-Y.; Mei, T.-S.* “Palladium-Catalyzed Electrochemical C–H Bromination Using NH4Br as the Brominating Reagent” Org. Lett. 2019, 21, 2645–2649.
4. Ma, C.; Zhao, C.-Q.; Xu, X.-T.; Li, Z.-M.; Wang, X.-Y.; Zhang, K.; Mei, T.-S.* Nickel-Catalyzed Carboxylation of Aryl and Heteroaryl Fluorosulfates Using Carbon Dioxide. Org. Lett. 2019, 21, 2464–2467.
5. Zhao, C.-Q.; Chen, Y.-G.; Qiu, H. Wei, L.; Fang, P.; Mei, T.-S.* “Water as a Hydrogenating Agent: Stereodivergent Pd-Catalyzed Semihydrogenation of Alkynes” Org. Lett. 2019, 21, 1412–1416.
6. Chen, Y.-G.; Shuai, B.; Xu, X.-T.; Li, Y.-Q.; Yang, Q.-L.; Qiu, H.; Zhang, K. Fang, P.; Mei, T.-S.* “Nickel-catalyzed Enantioselective Hydroarylation and Hydroalkenylation of Styrenes” J. Am. Chem. Soc. 2019, 141, 3395–3399.
7. Liu, D.; Ma, H.-X.; Fang, P.; Mei, T.-S.* “Nickel-Catalyzed Thiolation of Aryl Halides and Heteroaryl Halides via Electrochemistry” Angew. Chem. Int. Ed. 2019, 58, 5033–5037.
8. Yang, Q.-L.; Li, C.-Z.; Zhang, L.-W.; Li, Y.-Y.; Tong, X.; Wu, X.-Y.; Mei, T.-S.* “Palladium-Catalyzed Electrochemical C？H Alkylation of Arenes” Organometallics 2019, 38, 1208–1212.
9. Yang, Q.-L.; Wang, X.-Y.; Lu, J.-Y.; Zhang, L.-P.; Fang, P.; Mei, T.-S.* “Copper-Catalyzed Electrochemical C–H Functionalization of Arenes with Secondary Amines” J. Am. Chem. Soc. 2018, 140, 11487–11494.
10. Ma, C.; Fang, P.; Mei, T.-S.* “Recent Advances in C–H Functionalization Using Electrochemical Transition Metal Catalysis” ACS. Catal. 2018, 8, 7179–7189.
11. Jiao, K.-J.; Li, Z.-M.; Xu, X.-T.; Zhang, L.-P.; Li, Y.-Q.; Zhang, K.; Mei, T.-S.* “Palladium-catalyzed reductive electrocarboxylation of allyl esters with carbon dioxide” Org. Chem. Front. 2018, 5, 2244–2248.
12. Chen, Y.-G.; Xu, X.-T.; Zhang, K.; Li, Y.-Q.; Zhang, L.-P.; Fang, P.; Mei, T.-S.* “Transition-Metal-Catalyzed Carboxylation of Organic Halides and Their Surrogates with Carbon Dioxide” Synthesis 2018, 50, 35–48.
13. Yang, Q.-L.; Fang, P.; Mei, T.-S.* “Recent Advances in Organic Electrochemical C–H Functionalization” Chin. J. Chem. 2018, 36, 338–352.
14. Chen, Y.-G.; Shuai, B.; Ma, C.; Zhang, X.-J.; Fang, P.; Mei, T.-S.* “Regioselective Ni-Catalyzed Carboxylation of Allylic and Propargylic Alcohols with Carbon Dioxide” Org. Lett. 2017, 19, 2969–2972.
15. Li, Y.-Q.; Yang, Q.-L.; Fang, P.; Mei, T.-S.*; Zhang, D.* “Palladium-Catalyzed C(sp2)–H Acetoxylation via Electrochemical Oxidation” Org. Lett. 2017, 19, 2905–2908.
16. Ma, C.; Zhao, C.-Q.; Li, Y.-Q.; Zhang, L.-P.; Xu, X.-T.; Zhang, K.; Mei, T.-S.* “Palladium-catalyzed C–H activation/C–C cross-coupling reactions via electrochemistry” Chem. Commun. 2017, 53, 12189–12192.
17. Jiao, K.-J.; Zhao, C.-Q.; Fang, P.; Mei, T.-S.* “Palladium-catalyzed C–H functionalization with electrochemical oxidation” Tetrahedron Lett. 2017, 58, 797–802.
18. Yang, Q.-L.; Li, Y.-Q.; Ma, C.; Fang, P.; Zhang, X.-J.; Mei, T.-S.* “Palladium-Catalyzed C(sp3)–H Oxygenation via Electrochemical Oxidation” J. Am. Chem. Soc. 2017, 139, 3293–3298.
19. Liu, T.; Mei, T.-S.; Yu, J.-Q.* “gamma, delta, epsilon-C(sp3)–H Functionalization through Directed Radical H-Abstraction” J. Am. Chem. Soc. 2015, 137, 5871–5874.
20. Mei, T.-S.; Patel, H. H.; Sigman, M. S.* “Enantioselective construction of remote quaternary stereocentres” Nature 2014, 508, 340–344.
21. Mei, T.-S.; Werner, E. W.; Burckle, A. J.; Sigman, M. S.* “Enantioselective Redox-Relay Oxidative Heck Arylations of Acyclic Alkenyl Alcohols using Boronic Acids” J. Am. Chem. Soc. 2013, 135, 6830–6833.
22. Mei, T.-S.; Leow, D.; Xiao, H.; Laforteza, B.; Yu, J.-Q.* “Synthesis of Indolines via Pd(II)-Catalyzed Amination of C–H Bonds” Org. Lett. 2013, 15, 3058–3061.
23. Werner, E. W.; Mei, T.-S.; Burckle, A. J.; Sigman, M. S.* “Enantioselective Heck Arylations of Acyclic Alkenyl Alcohols Using a Redox-Relay Strategy” Science 2012, 338, 1455–1458.
24. Leow, D.; Li, G.; Mei, T.-S.; Yu, J.-Q.* “Activation of remote meta-C–H Bonds assisted by an 'end-on' template” Nature 2012, 486, 518–522.
25. Mei, T.-S.; Kou, L.; Engle, K. M.; Yu, J.-Q.* “Heterocycle Formation via Palladium-Catalyzed C–H Funtionalization” Synthesis 2012, 44, 1778–1791.
26. Engle, K. M.; Mei, T.-S.; Wasa, M.; Yu, J.-Q.* “Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions” Acc. Chem. Res. 2012, 45, 788–802.
27. Engle, K. M.; Mei, T.-S.; Wang, X.; Yu, J.-Q.* “Bystanding F+ Oxidants Enable Selective Reductive Elimination from High-Valent Metal Centers in Catalysis” Angew. Chem. Int. Ed. 2011, 50, 1478–1491.
28. Yoo, E. J.; Ma, S.; Mei, T.-S.; Chan, K.; Yu, J.-Q.* “Pd(II)-Catalyzed Intermolecular C–H Amination with Alkylamine Surrogates” J. Am. Soc. Chem. 2011, 133, 7652–7655.
29. Mei, T.-S.; Wang, D.-H.; Yu, J.-Q.* “Expedient Drug Synthesis and Diversification via ortho-C–H Iodination Using Recyclable PdI2 as the Precatalyst” Org. Lett. 2010, 12, 3140–3143.
30. Vikers, C. J.; Mei, T.-S.; Yu, J.-Q.* “Pd(II)-Catalyzed o-C–H Acetoxylation of Phenylalanine and Ephedrine Derivatives with MeCOOOtBu/Ac2O” Org. Lett. 2010, 12, 2511–2513.
31. Mei, T.-S.; Wang, X.; Yu, J.-Q.* “Pd(II)-Catalyzed Amination of C–H Bonds Using Single-Electron or Two-Electron Oxidants” J. Am. Chem. Soc. 2009, 131, 10806–10807.
32. Wang, X.; Mei, T.-S.; Yu, J.-Q.* “Versatile Pd(OTf)2？2H2O-Catalyzed ortho-Fluorination Using NMP as a Promoter” J. Am. Chem. Soc. 2009, 131, 7520–7521.
33. Wang, D.-H.; Mei, T.-S.; Yu, J.-Q.* “Versatile Pd(II)-Catalyzed C？H Activation/Aryl？Aryl Coupling of Benzoic and Phenyl Acetic Acids” J. Am. Chem. Soc. 2008, 130, 17676–17677.
34. Li, J.-J.; Mei, T.-S.; Yu, J.-Q.* “Synthesis of Indolines and Tetrahydroisoquinolines from Arylethylamines by PdII-Catalyzed C–H Activation Reactions” Angew. Chem. Int. Ed. 2008, 47, 6452–6455.
35. Mei, T.-S.; Giri, R.; Maugel, N.; Yu, J.-Q.* “PdII-Catalyzed Monoselective ortho-Halogenation of C–H Bonds Assisted by Counter Cations: a Complementary Method to Directed ortho-Lithiation” Angew. Chem. Int. Ed. 2008, 47, 5215–5219.
承担科研项目情况
2018/6–2020/6 上海科委基础研究项目
2018/1–2021/12 国家自然科学基金面上项目
2016/1–2019/12 国家自然科学基金面上项目
2015/7–2017/6 上海市浦江人才计划
2015/1–2017/12 国家自然科学基金创新研究群体基金
