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Dimiter S. Dimitrov Dr.Dimitrovandhisresearchgroupareexpertsindisplay/screening/librariesmethodologies,antibodyengineering,andproteinbiochemistry,structuralbiologyandcomputationalbiologyaswellasvirology,immunologyandcancerbiology.Hismajorlong-termgoalisthedevelopmentofclinicallyusefultherapeuticsandvaccinesagainstcancer,HIV-1andemergingandbiodefense-relatedvirusesaswellasotherrelateddiseasesincludingimmunedisorders.ThebiologicaltherapeuticsandvaccinesarebasedonhumanmonoclonalantibodiesinseveralformatsincludingfullsizeantibodiestypicallyIgG1s,engineeredantibodydomains(eAds),chimericantigenreceptors(CARs),bispecificandmultispecificantibodies,antibody-drugconjugates(ADCs),bi-specificT-cellengagers(BiTEs)andbi-specifickiller-cellengagers(BiKEs).
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