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Kevan M. Shokat KevanM.Shokat,ProfessorofUniversityofCaliforniaSanFrancisco,SanFrancisco,U.S.A.Researchinhislaboratoryisfocusedonthediscoveryofnewchemicalbasedtoolstodeciphercellularsignalingnetworkswithanemphasisonproteinkinasesandmorerecently,GTPases.Theanalysisofsignaltransductionpathwayshasprovenchallengingusingthetraditionaltoolsofbiochemistry,genetics,andchemistry.Biochemicalapproachesareoftenlimitedinutilitybecausesignalingnetworksspanfromthecellsurfacetothecontroloftranscriptionandtranslation,confoundingreconstitutioneffortsfrompurifiedproteins.Geneticapproachesallowspecificperturbationofsinglecomponentsinanintactcellororganism,yetareoftenconfoundedbytheemergentpropertiesofsignalingcascades.Chemicalandpharmacologicalapproachesenablerapid,reversible,andgraded(dose-dependent)inactivationofsinglecomponentsinintactcellsororganisms.Unfortunately,highlyselectivechemicalprobes(agonists,antagonists,traceablesubstrates,etc.)ofproteinkinasesaredifficulttodevelopbecausethe500proteinkinasessharehighlyhomo
Jack Flanagan JackFlanagan,SeniorResearchFellowofUniversityofAuckland.JackFlanaganobtainedhisBSc(Hons)inBiochemistryandMolecularGeneticsatVictoriaUniversityofWellington,NewZealand,andwasawardedaPhDscholarshiptostudyattheJohnCurtinSchoolofMedicalResearch,AustralianNationalUniversity,AustraliawhereheinvestigatedstructurefunctionrelationshipsfortheglutathionetransferaseclassofdetoxicationenzymeinthelaboratoryofProfPhilipBoard.AfterapostdoctoralpositionresearchingstructurefunctionrelationshipsinthemajordrugmetabolisingcytochromesP450underProfRolandWolfattheBiomedicalResearchCentre,UniversityofDundee,UnitedKingdom,hetookupaHowardFloreyCentenaryFellowshipattheInstituteforMolecularBiosciences,UniversityofQueensland,AustralialookingatinhibitordiscoveryforthehumanhematopoieticprostaglandinD2synthaseenzyme.CurrentlyaSeniorResearchFellowattheAucklandCancerSocietyResearchCentre,Jackisinvolvedinintegratingmolecularmodellingandvirtualscreeningmethodsofinhibitordiscoveryintoanumberofcurrentmedicinalchemistryprojec
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